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The primary outcome was noninferiority of HbA1c change at 40 weeks with orforglipron compared with dapagliflozin

Spoon-shaped nails are characterized by their concave shape and often thin and brittle

Together, these results indicate that ROS accumulation induced by SYNCRIP deficiency is predominantly associated with ferroptosis rather than apoptosis

Ethics declarations Ethics approval and consent to participate This study received approval from the Institutional Review Board (IRB) of the Federal University of Minas Gerais (UFMG) (CAAE3768820.1.0000.5149)