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Although 1,25(OH)D does not significantly increase TGF- expression in LCs, the inherently high basal levels of TGF- in LCs enable them to retain their Treg-inducing capacity [142, 144]

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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression

Gorca A, Huk-Kolega H, Piechota A, Kleniewska P, Ciejka E, Skibska B