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In vacuoles of macrophages where phagocytosed bacteria are killed, itaconate inhibits the bacterial enzyme, isocitrate lyase (ICL), a bacterial enzyme required for the glyoxylate shunt that functions during host infection by bacteria

59 Among pivotal patients with BBS who were greater than or equal to 18 years of age, | || || || || | of patients achieved a clinically meaningful ( 5%) reduction in body weight and | || || || achieved a greater than or equal to 10% reduction in body weight after 52 weeks of setmelanotide treatment