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Novel treatments Lysosomal enhancer-associated dysfunction plays a central role in the pathogenesis of PD by impairing the degradation of alpha-synuclein (-Syn), leading to the accumulation of toxic aggregates that exacerbate neuronal damage [116]

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Furthermore, for the isoprenoid tail to be attached, 4-HB must be transported into the mitochondrial matrix, where the condensation with the tail occurs