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Aberrant DNA methylation patterns have been identified in patients with HT, leading to gene silencing and altered expression of genes regulating the immune response, along with hypermethylation of specific CpG sites

These changes can interfere with how the medication is absorbed

For example: Tirzepatide (Zepbound) shows the greatest mean weight loss and is also approved for obstructive sleep apnea, but semaglutide (Wegovy) is preferred for those with cardiovascular or kidney complications or metabolic-associated steatohepatitis (MASH) due to broader FDA approvals

Most patients notice visible results in 2 to 4 weeks, with full improvements appearing over several months