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While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

Stability & Half-Life Data Plasma half-life: Approximately 30 minutes after intraperitoneal administration in rodent pharmacokinetic studies

In a rat hemorrhage model established with 5% ethanol and dry yeast, catalpol intervention improved the pathological state of the rats (Zhang, 2023)

Similar to cerebrovascular reactivity, impaired neurovascular coupling is attenuated with advanced age (Peng et al., 2018), MCI and ADRD (Phillips et al., 2016