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A fatty-acid side chain lets semaglutide bind albumin and resist enzymatic degradation, which is what makes once-weekly subcutaneous dosing possible

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Microbial metabolites and brain signaling Beyond GLP-1 itself, the metabolites produced by the three Pendulum strains have independent effects on brain-gut communication

J Clin Endocrinol Metab 81(1):327332 Zinman B, Hoogwerf BJ, Durn Garca S, Milton DR, Giaconia JM, Kim DD et al (2007) The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial