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Our results showed increased expression of fibroblast activation protein (FAP) together with markers of autophagy, inflammation, and oxidative stress in UF patients, which were all more markedly upregulated in obese compared to non-obese patients

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10.3390/nu12113254 36 DidangelosT.KarlaftiE.KotzakioulafiE.MargaritiE.GiannoulakiP.BatanisG.et al (2021)

"The triple-agonist design of Retatrutide offers an unprecedented mechanism of action, targeting multiple synergetic metabolic pathways to optimize energetic homeostasis in laboratory models." Preclinical in-vitro models indicate that GIP and GLP-1 receptor activations synergistically stimulate glucose-dependent insulin secretion, while glucagon receptor activation increases cellular energy expenditure and fatty acid oxidation