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It is important to note that microbes can synthesize not only thiamine but also thiamine antagonists

While there is no clear evidence that semaglutide directly harms the eyes, there are some potential concerns about how the drug might affect eye health, particularly in people with conditions like glaucoma

In clinical trial settings, retatrutide is administered as a once-weekly subcutaneous injection into the abdomen or outer thigh

The use of GLP1s was initially pioneered by bodybuilders in the late 2010s, who discovered that the medication could help with weight loss, and this led to further research and development of the drug for obesity treatment 4m10s