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These cells play fundamental roles, both in brain development by promoting the maturation of neurons and oligodendrocytes [52] and in the adult brain, by performing functions typical of macrophages such as phagocytosing various types of cellular debris and pathogens, but also regulating and maturing synapses through phagocytosis and the release of various factors, including cytokines, chemokines and extracellular vesicles [53,54]

Vitamin B12 Though not a direct effect of fasting, low Vitamin B12 levels can occur with reduced overall food intake or long-term use of certain medications (including metformin, which is sometimes co-prescribed with semaglutide)

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Across clinical trials, acute pancreatitis occurred in less than 1% of people taking tirzepatide at any dose