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In turn, LATS1/2 phosphorylate YAP/TAZ to inactivate them, promoting their cytoplasmic localization [86]

Bile duct explant culture EHBDs from 2-week- ( n 12 per genotype) and 16-week- ( n 5 per genotype) old Mdr2 / mice were dissected, incubated, in biliary epithelial cell media (BEC) 65 , and treated with or without the addition of 5M NAC (A9165, Sigma-Aldrich)