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The key milestones include: exenatide approval (2005), liraglutide approval (2010), semaglutide injection approval (2017), oral semaglutide with SNAC approval (2019), orforglipron cryo-EM structure published (2020), orforglipron Phase 2 results in NEJM (2023), orforglipron Phase 3 ATTAIN-1 results in NEJM (2025), and FDA regulatory submission (2025)

Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives

Alcohol consumption on DSIP nights is inadvisable, as alcohol already disrupts sleep architecture and combining it with DSIPs effects creates unpredictable outcomes

Taking 300 mg of alpha-lipoic acid daily for up to 6 months does not improve alcoholic liver disease