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From 2008-2010, Sanofi-Aventis Acomplia (selective CB1 antagonist) and Abbott Laboratories Meridia (NE/5-HT reuptake inhibitor)--both also designed to suppress appetite--were pulled from the market over similar cardiac safety concerns

Continuing to increase the dose or incur that expense can be counterproductive. Without insurance coverage, these medications can cost more than $1,000 per month, which can make long-term use difficult to justify for some patients especially if results are limited

This sequence spans the region exhibiting a significant perturbation or notable increase in the hetNOE value

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