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Other oxidative stress triggers include a poor diet, low physical activity, prolonged stress, and intrinsic factors, such as mitochondrial dysfunction leading to reduced adenosine 5-triphosphate (ATP) production, inflammation, and hypoxia (106, 117)

GIP Receptor Activation: The Metabolic Amplifier GIP receptor (GIPR) agonism is the primary driver of retatrutides potent effect on lipid metabolism and glucose control