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To address therapeutic non-response, combined biomarker prediction, multi-omic network reconstruction, and AI-driven dynamic monitoring have been employed to enable early identification of primary non-responders and patients with secondary loss of response

Recent data reported by the International Diabetes Federation (IDF) in 2021 have demonstrated that the global prevalence of diabetes was estimated at 10.5% (approximately 537 million people) ( Glucagon-like peptide-1 (GLP-1) is an insulin-promoting hormone and can enhance glucose-dependent insulin secretion, inhibit glucagon secretion and delay gastric emptying