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By preventing this degradation, DPP-4 inhibitors increase the levels and prolong the activity of incretin hormones, leading to enhanced insulin secretion and suppressed glucagon release in a glucose-dependent manner

Also, mTORC1 activate GLS through S6K1/eIF4B-dependent mRNA translation of c-myc , leading to GLS expression by repressing miR-23a/b [20,95]

More than half of the population that reaches 80 years of age or older develop clinically significant cataracts, according to the National Eye Institute