glp-1 drugs for obesity Another Weight-Loss Trial Win Weekly Drug GLP-1 analogs, new trend in

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In addition, novel regulators such as RNA methylation enzymes (METTL3/14) that modulate GPX4 mRNA stability (176), or RhoA-mediated vascular remodeling that enhances iron leakage into subchondral bone ( Future research should leverage high-resolution single-cell or spatial omics, functional validation in cell-specific knockout models, and joint-region-targeted delivery systems to develop more personalized and mechanistically guided ferroptosis interventions

Orbitrap-Fusion mass spectrometer (Thermo Finnigan, San Jose, CA) was used for mass spectrometry analysis

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