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MTC is a rare thyroid cancer, and while a causative relationship between these medications and MTC has not been proven, MTC did develop in animals at clinically relevant doses during drug development

Balanced Feedback While most Brello reviews are glowing, some users mention that GLP-1 medications can take time to adjust to and may cause mild side effects (like nausea) early on

Rodent Thyroid Differences : Rats and mice have a higher number of GLP-1 receptors on their thyroid C-cells compared to humans, making their thyroids more sensitive to the hormone

Cobalamin, bound to intrinsic factor, can then bind to a receptor complex called cubilin present on the apical membranes of enterocytes in the distal ileum as well as on renal epithelial cells of the nephron in the kidney