Standard clinical escalation protocol The Phase 2 trial published in the New England Journal of Medicine established the titration schedule that most researchers follow
Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG et al (2003) The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults
K., Szeleszczuk, ., Gubica, T., Zieliska-Pisklak, M., Bethanis, K., Christoforides, E., Dudek, M
Additionally, micelles can actively deliver drugs to specific cell types by conjugating with antibodies, sugar moieties or cell-penetrating peptides and exhibit lower complement activation than liposomes, thereby potentially reducing nanomaterial-related adverse effects [92]