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Abnormal mitochondria in salivary gland epithelial cells may act as DAMPs to trigger the formation of the local immune microenvironment ( pSS is one of the most prevalent systemic autoimmune diseases that is characterised by a triad of manifestations: dryness, pain and fatigue ( The salivary gland epithelium is composed of acinar cells, ductal cells, MECs and progenitor cells

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Immunohistochemical findings Immunostaining for CD68 and F4/80 was used to assess the early inflammatory response, specifically focusing on macrophage presence within the grafts