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There were fears that dosages over an upper tolerable limit may enhance the risk of kidney stones, iron toxicity, vitamin B12 deficiency, copper deficiency, dental enamel erosion, and diarrhoea, amongst others

CagriSema, the combination of cagrilintide 2.4 mg and semaglutide 2.4 mg, produced an estimated mean body weight reduction of 20.4% compared to 3.0% with placebo