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R 5 is H, or C 1 -C 6 alkyl

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Importantly, NNMT is a dominant component of the gene expression signature for sarcopenia, overexpression of which could lead to significantly reduced levels of NAD+ and associated declines in muscle mass, strength, and function that accompany aging

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[PMC free article] [PubMed] [Google Scholar] 79.Takhtfooladi H.A., Hesaraki S., Razmara F., Takhtfooladi M.A., Hajizadeh H

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