Currently, inherited genetic predisposition (especially NF1) and prior therapeutic radiation are considered the predominant and most clearly established risk factors
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The availability of ongoing clinical trials will provide critical data on their long-term efficacy, safety, and role in combination therapy with existing antihypertensive agents
Functional enrichment analysis indicated these intersecting genes are primarily involved in biological processes including oxidative stress responses, smooth muscle cell proliferation, and reactive oxygen species (ROS) responses, closely matching RA pathological features such as excessive inflammatory factor release and oxidative stress injury ( We further applied three classical machine learning algorithms (LASSO, RFE-RF, and SVM) to cross-validate and identify two core genes, GPX3 and MYC, which were subsequently validated using an MLP model
