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Some of the drawbacks of semaglutide include: Potential side effects Semaglutide can come with a variety of possible side effects depending on the person
Importantly, GLP-1 loses its inhibitory effect on glucagon secretion when blood glucose levels fall, allowing an appropriate glucagon response to hypoglycaemia
If you suspect your constipation is a side effect of your medication, you can report this through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or the Yellow Card app)
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