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248 In smokers, whom have been proven in multiple studies to have low blood levels of vitamin C, oral supplementation with 2 grams vitamin C per day has been shown to significantly decrease urinary isoprostanes, 249 markers of oxidative stress, and monocyte adhesion to the endothelial lining of blood vessels, one of the early stages in the development of dangerous atherosclerotic plaque

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In turn, the elevated antioxidant levels elevate the levels of plasma HSPs

Dosing for specific applications and populations While the standard protocols apply broadly, certain research contexts may benefit from adjusted approaches