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Ogut, D., Reel, B., Gonen Korkmaz, C., Arun, M.Z., Cilaker Micili, S., and Ergur, B.U., Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-B signaling in LPS-induced PC3 cells, Folia Histochem

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However, Treg cells inhibit immune responses by secreting IL-10 and TGF- and can directly interact with effector T cells to suppress the activity of antitumor immune cells, aiding tumor cells in evading immune surveillance and attack ( Reportedly, lactate in the TME induces H3K18la modification, which regulates immune cell functions by enhancing the transcriptional activity of CD39, CD73, and CCR8 gene promoters