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In a 23-week randomized clinical trial in humans, individuals taking AOD-9604 at 1 mg daily had an average of 2.8 kg weight reduction compared to a 0.8 kg weight reduction in those taking a placebo

[DOI] [PMC free article] [PubMed] [Google Scholar] 193.Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, et al

Semaglutide works by mimicking GLP-1, a hormone that helps control blood sugar levels by causing the pancreas to release insulin, decreasing the production of glucagon, and slowing down the emptying of the stomach