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The authors arbitrarily (and acknowledge that it is arbitrary) recommend fasting from liquids for 4-8 hours (4 hours for no/low-carbohydrate clear liquids and 8 hours for high-carbohydrate clear liquids)

Of course, in a footnote to the guidance, FDA explained that it retains the authority to determine that the significant difference is merely a pretext for the compounding of copies of commercially available products, in which instance it could bring an enforcement action

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Oxidative stress is related to several aging conditions, and H 2 O 2 is used to create a stress-induced senescence model ( 2 O 2 (100 M, 4 h) to induce senescence, and dexamethasone (100 nM, 24 h pre-treatment +4 h treatment) was co-administered (Figure 6G)