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To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration

During HCV infection, for instance, in the acute phase, the activation of the Nrf2 pathway defends infected cells from inflammatory response, while during the chronic phase its inhibition restores the oxidative imbalance, thus favouring the virus persistence [140]

Psychological therapies and dietary interventions have also been employed to manage ADHD, complementing pharmacological treatments

Natural Product Communications , 8 (8), 10851088