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These enzymes catalyze the reduction of H 2 O 2 to H 2 O through the coupled oxidation of GSH to GSSG, which is subsequently reduced back to GSH by glutathione reductase and NADPH.Other enzymes that require thiol-reducing equivalents, such as peroxiredoxins and glutaredoxins, also utilize glutathione as a reductant, restoring their oxidation-sensitive active sites to their reduced state by maintaining them in a Enzyme function

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