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Analysis of the D dhar mutant showed that DHARs are required to couple hydrogen peroxide metabolism to glutathione oxidation, and that this is functionally important for downstream activation of the salicylic acid pathway

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Cystine deficiency has been shown to promote the development of ferroptosis in numerous cancer cells, indicating that it may be a treatment target in breast cancer (18)

However, there was an increase in adiponectin levels (a hormone associated with weight loss and insulin sensitivity) and a decrease in insulin levels and leptin (a hormone linked with appetite) in the alpha-lipoic acid group [13][14]