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The main difference is mechanism: cooling-based fat cell damage versus injectable fat dissolving for targeted pockets

Pioglitazone , a thiazolidinedione, directly enhances insulin sensitivity in adipose tissue and muscle but carries risks of weight gain, fluid retention, and bone fractures

Although it is typically not recommended to prescribe a drug to treat a condition other than what it is formally approved for, some physicians have prescribed Ozempic for prediabetes

has been critical of the drug as a weight loss method, saying that it focuses on symptoms of obesity rather than fixing what he classifies as root problems, such as food systems and exercise