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Its small size and copper-binding affinity underpin its bioactivity, distinguishing it from larger proteins or synthetic peptides

However, the evidence for cytotoxicity is scant, especially since normal transplacental antibody passage of anti-TPO Ab to the human fetus does not usually induce thyroid damage

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Seek immediate care if you develop high fever above 101F, severe back pain, or vomiting, as these indicate kidney involvement requiring urgent treatment