For instance, folate has been found to modify the level of methylation within exons 6 and 7 of the colonic p53 but not that of exon 8 ( Reference Kim, Pogribny and Salomon 66 )
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Therefore, further research on these compounds, including their isolation, structural elucidation, and characterization, is needed to evaluate their efficacy and safety
Oncogene 22 , 73697375 (2003)