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Indeed, our c-Fos analysis clearly demonstrate that treatment with sCT + liraglutide strongly increased the number of DVC-activated neurons, standing out the DVC as an essential hub for mediating the beneficial effect of amylin and GLP-1R analogs combinational therapy

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Y1-R-mediated effects on pancreatic islets Our experiments were also designed to determine whether peptides that are efficacious at lower concentrations and/or those that promote modified internalization/-arrestin recruitment might be capable of sustaining the beneficial effects beyond those currently observed while also reducing the frequency of adverse events