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Therefore, the immediate presentation of adverse effects and the parallel therapeutic effects might suggest an essential cause-consequence chain of events of Budd-Chiari and BPC 157 in rats, and in particular, a relation to the liver as the prime organ affected[26-32] and failure of its circulation

Acknowledgements Not applicable Funding This work was supported by grants: Zhejiang basic public welfare research program (Grant Numbers LGD21H250001 and LGD22H250001), Scientific Research Foundation of Zhejiang University City College (No.X-202102)

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