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Two-carbon tethered artemisinin-isatin hybrids: design, synthesis, anti-breast cancer potential, and in silico study

The redox electrode was calibrated using ZoBells solution (2.64 g K 4 [Fe(CN) 6 ].3H 2 O and 2.06 g K 3 [Fe(CN) 6 ].H 2 O dissolved in 500 mL pH = 7 0.15 mol/L Na 2 HPO 4 /KH 2 PO 4 buffer)

The concurrent inhibition of MEK (trametinib) and glutamine metabolism (V-9302) enhances antitumor efficacy by orchestrating the FOXO3a/FOXM1 axis and autophagy, leading to pyroptosis and cell cycle arrest (135)

Another advantage of disulfides is that they can be attached directly to the cysteine of the antibody, resulting in a cleavable linker with fewer atoms added to the drug-linker complex