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Originally developed to manage type 2 diabetes, these medications have rapidly gained recognition in the medical community for their impressive effectiveness in supporting significant and sustainable weight loss
Finally, a third group reflected SGLT2i influences on metabolites, comprising reversal of abnormalities in long-chain fatty acid uptake, provision of ketonaemia as an alternative fuel that augments autophagic flux, improvement in iron homeostasis (increasing the bioreactive Fe pool while lowering ferritin and hepcidin), and mitigation of cytosolic accumulation of harmful glucose and lipid by-products, accompanied by an overall enhancement of mitochondrial oxidative metabolism
Teixeira and Rumjanek, 2014) and inhibited in murine ones (Gao et al., 2022), which is primarily associated with the activation of signal cascades (Khalaf et al., 2019