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To view or add a comment, sign in Carbamazepine is one of the few medications that changes its own pharmacokinetics over time. Thats why it catches many clinicians off guard. A patient starts carbamazepine, improves during the first week, and the drug level looks therapeutic. A few weeks later, symptoms return. Adherence hasn't changed. The dose hasn't changed. So what happened? The answer is autoinduction. Carbamazepine induces the enzymes responsible for its own metabolism

This results in cancer of the melanocytes