However, GLP1 drugs are relatively large peptide molecules, which do not easily cross intact human skin on their own
The GLP-1 Microbiome Pathway (Simplified Flow) Nutrient intake Microbial fermentation Short-chain fatty acids (acetate, propionate, butyrate) FFAR2/FFAR3 receptor activation Enteroendocrine L-cell stimulation GLP-1 secretion This pathway links microbial ecology directly to hormone signaling
Thus, since transcriptomic atlases (HPA, GTEx, FANTOM5) suggest that GLP-1R is expressed in salivary glands, when activated, GLP-1R would engage the same cAMPPKAEPAC and PI3KAkt modules, potentially influencing [38,39,40]: Vesicle priming and exocytosis of salivary proteins (via cAMP signalling)
4: Youre in a plateau, not a failure Plateaus happen