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When administered in humans, GIP receptor antagonists conjugated to GLP-1 analogues have led to mild gastrointestinal-related adverse events, including nausea and vomiting ( 4 Combinations of GIP receptor targeting treatments and GLP-1 receptor agonism In recent years, GIP receptor agonists and antagonists have gained attention for their therapeutic potential in treating obesity and type 2 diabetes

Mechanistic investigations demonstrated that the anti-hypersensitivity effects of morroniside are mediated by its activation of spinal GLP-1R [73]

There is no universally accepted 1:1 conversion between GLP-1 RAs

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