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While GI side effects have been suggested to be involved in mediating the weight-loss effect of GLP-1RAs, analysis of large clinical trial data sets with liraglutide and semaglutide has shown that, while GI side effects may lead to more initial weight loss, they are not the mechanism of weight loss as many patients have weight loss and no side effects (182, 183)

Reduced blood pressure: Semaglutide can help lower blood pressure, which can reducethe risk of cardiovascular disease

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The treatment, in this case, usually follows by means of having daily injections for a week or so, then injections every few days for a month, after which maintenance doses are usually given every one to two months for life