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Int J Biochem Cell Biol

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This paper found a small-molecule G6PD activator that can increase activity and thermostability of Canton mutant R459L, opening the door for a potential therapeutic for G6PD deficiency

IR causes erythrocytes to extravasate to surrounding tissues and heme-iron is released via macrophage-mediated hemolysis in tissues, which is subsequently degraded to ferrous iron and other constituents [42]