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With their potential to revolutionise the treatment of T2D, obesity, and associated conditions, these drugs are set to become even more integral to global healthcare

The IR usually progresses in silence and manifests clinically years after being present in the form of hyperglycemia, favoring atherogenesis and plaque progression in a curvilinear relationship with vascular disease, even in the absence of hyperglycemia ( 2 O 2 and O 2 activate stress-sensitive serine/threonine kinases such as JNK, IKK, and PKC, which phosphorylate IRS-1 at inhibitory serine residues (Ser307, Ser612), disrupting its interaction with the insulin receptor and promoting proteasomal degradation (Roden et al., 2017)

Waist circumference decreased by 1.38 cm on average

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen) reduce inflammation and pain through cyclooxygenase inhibition