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From charcot to lou gehrig: Deciphering selective motor neuron death in ALS

Generally, long-term data (like 2-3 years out) from trials show maintained improvements in weight and health markers with no new safety concerns

We understand that betablockers are effective in treatment of chronic HF, however, the official ESC guidelines for the management of HF patients with T2DM ( 1st generation non-selective betablockers block both 1 and 2 receptors, thus decreasing insulin secretion, glycolysis and lipolysis, while increasing glycogenolysis and gluconeogenesis and are prone to mask the symptoms of hypoglycemia (148, 149)

It is not a legitimate therapeutic in any regulatory sense