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Unlike caloric restriction, which triggers adaptive metabolic reprogramming, including enhanced autophagy and neuronal plasticity 69,70 , semaglutide primarily reduces food intake through appetite suppression 71

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In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates