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Upon binding, transcription of genes encoding proteins necessary for the repair of photodamaged skin, growth and differentiation of keratinocytes, anti-inflammatory actions, and the suppression of sebum production takes place.[19,20] As early as the 1970s, the use of topical retinoids for various skin diseases, particularly acne vulgaris, began to be increasingly reported.[21] While the role of retinoids in keratinocyte growth and differentiation has been widely recognized for several decades, their influence on the biological function of sebocytes is now becoming more known

Bibliography 1.Ming-Jer.H, Cheng-Hung.L, Ho-Yen.C, Gwo-Jyh.C, Hsiu-Yun.H, Yuling.L, Jong.P, Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway

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