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Chronic pain conditions were strongly associated with FC, including rheumatological/arthritic pain [aPR: 1.57, 95% CI: 1.37-1.80], neuropathic pain [aPR: 1.49, 95% CI: 1.21-1.82], headache, back-, fracture-, or morbid pain [aPR: 2.07, 95% CI: 1.78-2.41], and non-specific pain, CRPS, or fibromyalgia [aPR: 1.57, 95% CI: 1.37-1.81]

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Leptin acts as a signaling molecule in the hypothalamic-pituitary-gonadal axis.[ref] Low leptin levels, such as when someone is very thin, can cause amenorrhea or lack of a menstrual cycle

Evaluation of rosmarinic acid against myocardial infarction in maternally separated rats