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Oral antidiabetic drugs remain the cornerstone of therapy for type 2 diabetes mellitus however, conventional immediate release formulations often suffer from short biological half lives, frequent dosing requirements, fluctuating plasma drug concentrations, and reduced patient compliance

Plasma levels decline with age, dropping roughly 60 percent between age 20 and age 60

Advanced atherosclerotic plaques exhibit intra-plaque (IP) angiogenesis

It is likely that problematic food and drug cravings share a similar biological basis, and next-generation medicines may be more powerful or more targeted to one or the other