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Although intracellular Cys is not only provided by System X c , but also by transsulfuration pathway (Hayano et al., 2016) and the neutral amino acid transporter ( c is dysfunctional, it will still lead to intracellular Cys deficiency, and GSH depletion, making the cell highly sensitive to ferroptosis

The acrophase was calculated as occurring at 0718 h in the young group and 0705 h in the older men

In clinical studies, higher levels of circulating long- and medium-chain acylcarnitines showed mixed results in patients with Alzheimers disease [24, 25] whereas clinical trials of patients with Parkinsons disease have consistently shown that circulating levels of long-chain acylcarnitines are decreased [26,27,28]

However, findings from these genetic risk factors for disease associated with high UA have been applied to identifying risk genes for low UA in PD